M Brothers at Mayo

Jacksonville, FL · New American restaurant

Rating
4.6/5
★★★★★ 4.6
Reviews
20
Rank in Jacksonville
#401
of 2707 restaurants
City Percentile
72%
rating percentile
Address
M Brothers at Mayo, 14335 Hospital Dr Suite 100, Jacksonville, FL 32224
Phone
(904) 953-0409
Website
mbrothersatmayo.medurebrothers.com
Status
Closed · Opens 5 PM

M Brothers at Mayo is a restaurant located in Jacksonville, FL. It is one of 2,707 restaurants listed in Jacksonville. Its 4.6-star rating is above the Jacksonville city average of 4.2 stars. There are 10 photos associated with this location.

About M Brothers at Mayo

Located inside Jacksonville's Mayo Clinic, M Brothers is the newest venture by the Medure Brothers. Our menu features fresh seafood with an Asian and Mediterranean flair

Hours

Saturday5 PM–9 PM

Customer Reviews

★★★★★ 5.0 Gary Zolle Stone · Feb 2026

I had the distinct pleasure recently of dining at M Brothers at Mayo, while waiting at Mayo Clinic Hospital for a relatives outpatient surgery to be completed. I was as impressed with the restaurant detail and food, as I was with the efficiency and attention to detail of the hospital itself. This is definitely an unexpected dining oasis, that I had heard about, but had never previously enjoyed. Great ambiance, service from Kaleen, and fare, especially the House-Made Breads and Salads. It's not often that you would consider a trip to the hospital solely to dine, but an M Brothers at Mayo experience does it! I only wish we had time for the dessert!

★★★★★ 5.0 Renee Murphey · Jan 2026

Oh my goodness I was so very impressed with the food qualiity and atmosphere of this restaurant! Exexutive Chef Thomas Rivers and his staff blew us away with these delicious appetizers which began our journey. Each delightful aspect was perfectly prepared and the presentation was astounding. The meal continued with our main entrees which unfortunately I was so anxious to devour i failed to get a photo but were nothing shy of exquisite! And alas the happy ending of an assortment of delectable desserts which were hand prepared and delivered by Chef Thomas himself. Our experience was a once in a lifetime experience that none of us will ever forget! Thank you for every detail of fine dining from the hostess, wait staff, outstanding service and of course Chef Thomas. We will definitely be back!

★★★★★ 5.0 Matthew Parks · Sep 2025

As usual, this latest offering was great. The ambiance was what you would expect from a high end restaurant. The tuna tacos were a amazing. The Fried chicken bao was good, but suffers from the same mistake lots of folks make, they chicken was not seasoned. I think they were anticipating that the sauce would be enough, but I am a Southern boy. The bao buns were soft and very complimentary to the crispiness of the chicken. The hostess and bartender were very cool. Overall, I would go back for a good night out to explore the rest of the menu. I was tempted by the poke bowl and the barbacoa iberico chop. Has to get back for some of that.

★★★★★ 5.0 Jessica Murphey · Jan 2026

The dining experience and food was out of this world amazing! It was so great to catch up with friends while enjoying some deliciously unique dishes and amazing ambiance. The Executive Chef Thomas Rivers even came out to the table to explained every dish like it was a work of art. We will definitely be back and this is the perfect place for dinner with friends, date night or even take an extended lunch if you work at Mayo Clinic! Thank you Thomas for feeding us such amazing food, we will definitely be back!

★★★★★ 5.0 Parvati Ananda · Jan 2026

During my brother’s admission to Mayo, my husband and I ate this restaurant several times. Always an amazing experience. One Saturday night after 9:00, we were walking around on a “hot sauce mission “ for my brother. We saw the door still open and a server walking by. Heather proceeded to help our plight and procured 3 small samples of hot sauce for us. This small act brought so much happiness to both us and my brother. This is the definition of hospitality-going above and beyond to create a memory. We will always remember this kindness.

Accessibility & Amenities

✓ Wheelchair Accessible Entrance ✓ Wheelchair Accessible Parking Lot ✓ Wheelchair Accessible Restroom ✓ Wheelchair Accessible Seating

Services

New American restaurantRestaurant

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This listing is informational. Contact the business directly to verify credentials, services, and availability.